Research studies in the U.S. and around the world indicate positive benefits of reflexology  for various conditions. In particular, there are several well-designed studies, funded by the National Cancer Institute  and the National Institutes of Health  that indicate reflexology's promise as an intervention to reduce pain and enhance relaxation, sleep, and the reduction of psychological symptoms, such as anxiety and depression . Perhaps the most beneficial results have been in the area of cancer palliation (Ernst, Posadzki, & Lee, 2010).
Kunz and Kunz (2008) have developed a summary of 168 research studies and abstracts from journals and meetings from around the world. Many of these studies originated in peer-reviewed journals in China and Korea. All of the studies had information about the frequency and duration of the reflexology application.
Based on the studies they reviewed, Kunz and Kunz identified four primary effects that reflexology demonstrates:
Here are some research examples that show reflexology to be effective for a wide variety of health concerns.
Williamson et al (2002) found that both reflexology and foot massage reduced anxiety and depression  in postmenopausal women. In addition to this study, see the studies listed under Cancer  Treatment.
These studies showed reduction of pain, nausea, diarrhea or constipation, and improved quality of life with reflexology.
Kim, Lee, Kang, Choi, and Ernst (2010) reviewed one randomized clinical trial (RCT) and three nonrandomized controlled clinical trials (CCTs), the only studies out of 60 potential studies to meet their criteria of controlled quantitative trials wtih physical or psychological outcomes. The studies showed significant reduction in pain, nausea/vomiting, and fatigue with reflexology, and improved sleep and mood. In short, all four studies suggested beneficial effects of reflexology for women with breast cancer. The problem, according to the authors, is that the flaws in the studies jeopardize the validity of their results. The RCT was rigorous, but because of its study design, it was "unable to demonstrate specific therapeutic effects of reflexology" (p. 329). Kim and colleagues contend that the CCT results suffer from selection bias.
Key to the understanding of these studies, and to the interpretation of all of the studies discussed in this section, is that it is terribly difficult to plan and execute a well-designed study that meets all of the parameters. These authors state that "the main limitations of the included studies were small sample sizes, inadequate control for nonspecific effects, a lack of power calculations, and short follow-up or treatment periods" (p. 329). Given that RCTs are the gold standard, blinding is always an issue. Inadequate blinding and inadequate allocation concealment are factors that could also contribute to selection bias, leading to enhanced treatment effects. The authors also suggest that studies should discuss adverse effects of the treatment, even if there are none. Their final conclusion, based on these four studies, was that there is "insufficient evidence for the effectiveness of reflexology as a symptomatic treatment for breast cancer. The risk of bias in the primary data that exists is high" (pp 329-330).
Frankel (1997) conducted a pilot study to identify the effects of reflexology and foot massage on the physiology of the body, measuring baroreceptor reflex sensitivity and the link between pressure to the feet, as well as the baroreceptors of the heart  (neurons).
Results showed that pressure sensors in the feet are linked to the same part of the brain as the baroreceptor reflex. This small, single-blinded study included 24 subjects - 10 received reflexology, 10 received foot massage, and 4 were the control.
Diabetes Type II
Ying (1998) conducted a controlled research study on reflexology and blood flow in patients with Type II Diabetes . Pre- and post-session, blood flow rate, time and acceleration were tested by Doppler ultrasonic equipment. Results showed that the blood flow improved for 20 patients receiving reflexology (there were 15 patients of normal health in the control group). This is a small sample however.
Brendstrup & Launse (1997) conducted a study in which 78 reflexologists treated 220 patients, the majority of whom had moderate to severe headache  symptoms. Three months after completing a reflexology session, 65% of patients reported that reflexology helped with symptoms, 19% stopped taking headache medications, and 16% stated that reflexology was a "cure."
Testa (2000) conducted a blind, random trial, in which 32 patients with headaches were evaluated after a session with foot reflexology and at a 3-month follow-up. Results showed that foot reflexology was at least as effective as drug therapy (Flunarizin).
Sudmeier et al. (1999) conducted a study with 32 healthy subjects. The blood flow of the three vessels of the kidney was measured before, during, and after foot reflexology using Doppler sonography. Results showed that organ-associate foot reflexology is effective in increasing renal blood flow during therapy (which helps the body transport nutrients to cells and remove wastes).
Gordon et al. (2010) compared the effectiveness of foot reflexology, foot massage, and regular treatment (control group) in children (1-12 years) with chronic idiopathic constipation over a 12-week period. The study design was a randomized control trial. The authors report that the reflexology group had the greatest increase in the number of bowel movements and the greatest reduction in constipation symptom scores. There were significant differences between reflexology and control groups; however, there was no significant difference between reflexology and massage for bowel frequency, and no significant difference between control and massage groups for bowel frequency or overall constipation symptom scores.
Dr. Jesus Manzanares, a physician from Spain, has spent years studying the neurophysiological basis for reflexology. Dr. Manzanares' research has identified and biopsied deposits (which reflexologists have traditionally referred to as "crystals") that were located in reflex areas of the feet. These deposits are associated with pain, contain nervous fibers, and have different characteristics based upon their degree of acuity or chronicity (Manzanares, 2007). A brief overview of his unpublished work can be found at his website (www.manzanaresmethod.com ).
Using thermographic pictures of the soles of the feet before and after reflexotherapy, along with similar pictures of the spinal column, Dr. Piquemal was able to show a change in the thermal pattern on the sole of the feet "that was reflected on the skin of the back for each of the five selected [cutaneous] zones" (2005). The importance of this research is that it ties reflexology work on the feet to blood flow of inner organs (lung, liver, stomach, pancreas, and small intestine), either through vasoconstriction or vasodilation via the autonomic nervous system. It appears that reflexology may be able to play a role in regulating blood flow disturbance, at least to these organs.
From their research in India, Choudhary, Kumar, and Singh (2006) reported two groups who received interventions postoperatively. Group I received foot reflexology for 15-20 minutes at transfer to the Recovery Room, 2 hours postoperatively. Group II received conventional pain medication (NSAID and Opiods). The results were statistically significant at all four time intervals for the reflexology group showing a decrease in use of medication over the conventional group. A significant decrease in pain was also noted in the reflexology group at all time intervals. When the pain score was compared before and after treatment in the reflexology group, statistical significance was seen at 2 and 6 hours postoperatively.
Using two groups for comparison, Choudhary and Singh (n.d.) also added hand reflexology to conventional medications for nausea and vomiting postoperatively. They found a significant decrease in the group who had reflexology plus conventional medication.
Premenstrual Syndrome (PMS)
Oleson & Flocco (1993) conducted a randomized, controlled study with 35 women with 38 premenstrual symptoms. The women recorded their symptoms on a 4-point scale in a daily diary. Symptoms were recorded for two months before reflexology therapy, two months during, and two months after. Results showed that 46% of the women had improved symptoms (such as less anxiety, depression, fatigue, or difficulty sleeping) with reflexology alone.
Healey et al. (2002) conducted a randomized, controlled study of 150 subjects examining reflexology for alleviation of chronic sinusitis. Participants who received reflexology therapy comprised the control group. The other two groups received nasal irrigation procedures. Results showed equal improvement in both groups.
In an article entitled "The Saline Solution?" Andrew Weil, MD, commented, "After two weeks of daily treatment, more than 70% of those practicing nasal douching reported improved symptoms. But surprisingly, the group that practiced reflexology massage - pressure to feet or hands, appeared to fare equally as well. The unexpected results for this technique may prompt further research."
A systematic review of reflexology studies was conducted by Ernst, Posadzki, and Lee (2011) to summarize and critically evaluate the effectiveness of reflexology in the treatment of human conditions. Twenty-three RCTs met their inclusion criteria, with 8 suggesting that reflexology had beneficial effects, 14 showing no effectiveness, and one being equivocal. Ernst and colleagues stated that in general, the quality of the studies was poor. Some of their observations are listed below:
The authors suggest that the distinction between reflexology as an alternative treatment and a medical treatment is not clear, and that the distinction should be more marked to avoid treatment errors and potential problems. They also recognize the strong bond that exists between many providers and their patients. They conclude by encouraging researchers to base future studies on the standards of the CONSORT (http://www.consort-statement.org/ ) for trial design and reporting.
Brendstrup, E & Launse, L. (1997). Headache and Reflexological Treatment. The Council Concerning Alternative Treatment, The National Board of Health, Denmark.
Choudhary, S., Kumar, G., & Singh, K. (Spring 2006). Reflexology reduces the requirement and quantity of pain killers after general surgery. Reflexology Across America. Retrieved from Reflexology Association of America website: http://www.reflexology-usa.org/assets/dr_shweta_research_study.pdf .
Choudhary, S. & Singh, T. (n.d.). Efficacy of reflexology in prevention of post-operative nausea vomiting. Retrieved from Reflexology Association of America website: http://www.reflexology-usa.org/assets/Dr_Shewta_Research_Post_Operative_Nausea.pdf .
Ernst, E., Posadzki, P., & Lee, M. (2011). Reflexology: An update of a systematic review of randomised clinical trials. Maturitas 68, 116-120. Retrieved from http://www.elsevier.com/locate/maturitas .
Gordon, J., Alder, E., Matthews-Smith, G., Hendry, I., & Wilson, D.(November 2010). The effectiveness of reflexology as an adjunct to treatment in childhood idiopathic constipation: A single line randomised controlled trial (The SOCC Project). Paper presented by Amy Kreydin at the Reflexology Associaton of Canada Conference, Winnipeg, British Columbia.
Healey, D, et al. (2002). Nasal Irrigation for the Alleviation of Sinonasal Symptoms. Presented Sept 25 at the American Academy of Otolaryngology.
Frankel, B.S.M. (1997). The effect of reflexology on baroreceptor reflex sensitivity, blood pressure and sinus arrhythmia, Complementary Therapies in Medicine, 5, 80-84.
Hodgson, H. (2000). Does reflexology impact on cancer patients' quality of life?" Nursing Standard, 14(31), 33-38.
Kim, J-I., Lee, M., Kang, J., Choi, D., & Ernst, E. (2010). Reflexology for the symptomatic treatment of breast cancer: A systematic review. Integrative Cancer Therapies, 9. 326-330. doi: 10.1177/1534735410387423.
Kim M.S. et al. (2001). Effects of hand massage on anxiety in cataract surgery using local anesthesia. J Cataract Refract Surg, 27(6):884-90.
Kunz, B. & Kunz, K. (2008). Evidence-Based Reflexology for Health Professionals and Researchers: The Reflexology Research Series. This book can be purchased from http://www.reflexology-research.com/researchforresearchers.html .
Manzanares, J. (September 2007). The science behind reflexology deposits. Paper presented at the International Council of Reflexologists, Anaheim, California. Retrieved from Reflexology Association of America website: http://www.reflexology-usa.org/articles/manzanares_research_biopsy.pdf .
Milligan, M. et al. (2002). Int J. Oalliat Nurs, 8(10), 489-96.
Oleson, T & Flocco, W. (1993). Randomized controlled study of premenstrual symptoms treated with ear, hand, and foot reflexology. Obstetrics and Gynecology, 82(6), 906-11.
Piquemal, M. (September 2005). Global effect of reflexology on blood flow. Paper presented at the International Council of Reflexologists, Amsterdam and summarized by Christine Issel for the ICR Newsletter (Vol. 15, No. 1, March 2006, pp 18-19), reprinted at the Reflexology Association of America website: http://www.reflexology-usa.org/assets/Piquemal_Article.pdf .
Rahbar, M., Wyatt, G., Sikorskii, A., Victorson, D., & Ardjomand-Hessabi, M. (2011, in press). Coordination and management of multisite complementary and alternative medicine (CAM) therapies: Experience from a multisite reflexology intervention trial, Contemporary Clinical Trials. doi: 10.1016/j.cct.2011.05.015.
Sikorskii, A., Wyatt, G., Victorson, D., Faulkner, G., & Rahbar, M. (2009). Methodological issues in trials of complementary and alternative medicine interventions, Nursing Research 58(6), 444-451. Retrieved from http://www.nursing-research-editor.com .
Stephenson, N.L. et al. (2000). The effects of foot reflexology on anxiety and pain in patients with breast and lung cancer. Oncology Nursing Forum, 27(1), 67-72.
Sudmeier, I., et al. (1999). Anderund der nierendurchblutung durch organassozilerte reflexzontherapie am fuss gemussen mit farbkodierter Doppler-sonograhpie. Universitatsklinik fur Innere Medizin, Inssbruk, Austria. Forsch Komplementarmed, 6(3), 129-34.
Testa, G.W. (2000). A study on the effects of reflexology on migraine headaches. Accessed on May 24, 2007, from http://members.tripod.com/GTesta/Dissertationall.htm .
Ying, Ma. (1998). Clinical observation demonstrated the influence upon arterial blood flow in the lower limbs of 20 cases with type II diabetes mellitus treated by foot reflexology. China Reflexology Symposium Report, China Reflexology Association, Beijing, 97-99.
Weil, A. (January, 2002). The Saline Solution? Self Healing, p 2.
Williamson et al (2002). Randomised controlled trial of reflexology for menopausal symptoms. BJOG An International Journal of Obstetrics and Gynaecology, 109 (9) p 1050-1055.
Wyatt, G., Sikorskii, A., Bush, R., & Mukherjee, R. (2010). Team science of nursing, engineering, statistics, and practitioner in the development of a robotic reflexology device, Journal of the Society for Integrative Oncology, 8(1),14-19. doi: 10.2310/7200.2009.0017
Wyatt, G., Sikorskii, A., Rahbar, M., Victorson, D., & Adams, L. (2010). Intervention Fidelity: Aspects
of complementary and alternative medicine research, Cancer Nursing, 33(5), 331-342. doi: 10.1097/NCC.0b013e3181d0b4b7